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M94A3126.TXT
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1994-10-25
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Document 3126
DOCN M94A3126
TI Do corticosteroids predispose to infections or Kaposi's sarcoma in HIV+
patients with low CD4 counts?
DT 9412
AU Tetreault D; DeLeo M; Beck K; French C; Beall G; Harbor-UCLA Medical
Center, Torrance.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):148 (abstract no. PB0019). Unique
Identifier : AIDSLINE ICA10/94369449
AB OBJECTIVE: To determine if a causal relationship exists between systemic
corticosteroid (CS) use (greater than 1 week) and the development of
active cytomegalovirus disease (CMV), Kaposi's sarcoma (KS), and
cryptococcosis (Cr) in HIV+ patients with low CD4 cells. METHODS: Out of
256 adult patients with CD4 counts < 100/mm3 who were seen between April
1990 and January 1993, 90 charts were randomly selected for review.
Patients were divided into 2 groups: CS vs non-CS. Patients were
followed for up to 12 months (less if patients died or were lost to
follow-up). CMV, KS, and Cr events during this period were recorded.
RESULTS: Thirty-one of 90 patients received CS. Six events (19%)
occurred in 31 patients who received CS (2 CMV, 4 KS), and fourteen
events occurred in 13 patients (22%) who did not receive CS (8 CMV, 4
KS, 2 Cr) (P = 0.5 by Fisher's exact test). TABULAR DATA, SEE ABSTRACT
VOLUME. CONCLUSION: There was no significant relationship between the
use of CS and the development of CMV, KS, or Cr in this group of
patients.
DE Adrenal Cortex Hormones/*ADVERSE EFFECTS Adult AIDS-Related
Opportunistic Infections/*PHYSIOPATHOLOGY Comparative Study Follow-Up
Studies Human HIV Seropositivity/*PHYSIOPATHOLOGY Leukocyte Count
Sarcoma, Kaposi's/*ETIOLOGY Time Factors *T4 Lymphocytes MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).